Anticonvulsant and depressant-like activity of ursolic acid stearoyl glucoside isolated from Lantana camara L. (verbanaceae)

ObjectiveUrsolic acid stearoyl glucoside (UASG), a new terpenoid -isolated from Lantana camara L. was evaluated for its anticonvulsant and depressant activity of was in Wistar albino rats and Swiss mice.MethodsColumn chromatography was used to isolate UASG. The intraperitonial administration of UASG (25 and 50 mg/kg) produced a significant depressant effect on CNS. Anticonvulsant potential was experimentally proved and demonstrated through Maximal electroshock (MES) induced seizure, Isoniazid (INH) induced seizure and Assessment of locomotor activity test.ResultsAdministration of drug reduced spontaneous motor activity (P < 0.05), the number and lethality (P < 0.01 and P < 0.001) of Isoniazid (INH)-induced seizures and inhibition of hind limb extension in (P < 0.05 and P < 0.001) in Maximal Electroshock (MES)-induced seizures.ConclusionsResearch finding suggests that ursolic acid stearoyl glucoside possess anticonvulsant and depressant like effect.