| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3454737 | Asian Pacific Journal of Tropical Disease | 2012 | 6 Pages |
ObjectiveThe plant Rivea hypocrateriformis (RH) has numerous therapeutic utility in folk medicine having antidiabetic, antidepressant, analgesic as well as pregnancy irruption and anticancer properties. This led us to carry out the evaluation of plant for antimitotic, antiproliferative and cytotoxicity studies.Materials and MethodThe dried aerial parts of RH were successively extracted with petroleum ether, chloroform, ethanol and water. All extracts are subjected to in vitro Antimitotic and Antiproliferative assay by Allium cepa root inhibition and yeast model. The successive chloroform, SCH and ethanol extract, SEE was subjected to in vitro anticancer activity by SRB assay MCF-7, HOP-62, MOLT-4, HCT-15 and PRO cell lines.ResultsThe SCH and SEE shows significant antimitotic and antiproliferative activity. The mitotic index was found to be 12.14 and 14.24 mg/mL respectively, which was near to standard, Methothrexate 11.39. The IC50 value of antiproliferative assay was found to be 47.88 to 27.12 mg/mL for SCH and SEE respectively.ConclusionsBased on these results, it is concluded that RH may be the good candidate for the treatment of cancer as SCH and SEE are cytotoxic against various cell line in SRB assay.
