In vivo anti–nociceptive and anti–inflammatory activities of Lippia alba

ObjectiveTo evaluate antinociceptive and anti–inflammatory activities of Lippia alba (Mill.) N.E. Brown (Verbenaceae) leaves.MethodsSoxhlet extraction method was used to obtain extracts using petroleum ether extracts (PELA); chloroform extracts (CELA); ethanol extracts (EELA) and aqueous extract (AELA). Antinociceptive activity was assessed on rats by tail flick latency using tail immersion method and anti–inflammatory activity was estimated by carrageenan induced paw edema method. PELA, CELA and AELA at a dose of 500 mg/kg.b.wt. and EELA at a dose of 460 mg/kg.b.wt were administered orally.ResultCompeting to control AELA was found to have a higher range of anti–nociceptive activity and showing maximum (79.66%) response at 60 min, where as CELA and EELA were found to have a maximum range of anti–inflammatory activity and CELA exhibit maximum (19.5%) response at 240 min.ConclusionThe results suggest that the extracts of Lippia alba possess ant-inociceptive and anti–inflammatory activities, and its help to authenticates the use of the plant in the traditional treatment of ailments associated with pain and inflammation.