Synergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats

ObjectiveTo investigate the synergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats.MethodsRats were randomly divided into seven groups: (i) non-obese control (NOB), (ii) Obese control (OB), (iii) orlistat (50 mg/kg; p.o.), (iv) ethyl acetate extract of Commiphora mukul (gum resin) (200 mg/kg; p.o.), (v) ethanolic extract of Lagenaria siceraria (fruit) (200 mg/kg; p.o.) were examined individually, (vi) C. mukul and L.siceraria (200 mg/kg; p.o.) and (vii) C. mukul and L.siceraria (400 mg/kg; p.o.)extracts were administered in combination to the high fat-diet-induced obese rats for 30 days to evaluate its synergistic activity.ResultsFor synergistic effect, after combination treatment caused most significant (P < 0.001) reduction in body weight, fasting blood glucose, serum levels of cholesterol, triglyceride, LDL, VLDL and increase levels of HDL.ConclusionsThe result demonstrated that combination C.mukul and L.siceraria has ameliorated the high fat diet induced obesity.