IL-17A plays an important role in induction of type 2 diabetes and its complications

Type 2 diabetes (T2D) is the most prevalent metabolic disease worldwide. Previous studies revealed that immune responses, genetic factors, and inflammatory processes played important roles in the pathogenesis and complications of T2D. It has been documented that some people who have T2D are suffering from serious organ-specific pathophysiological conditions including nephropathy and retinopathy. The mechanisms responsible for progression of the disease and its long-term complications are yet to be clarified. IL-17A as a pro-inflammatory cytokine has a dual function, inducing early immune responses against infections and participating in autoimmunity and destructive inflammatory conditions. Therefore, the aim of this review was to address the recent information regarding the status and association of IL-17A with T2D and its related disorders.