Mutagenic and antimutagenic activities of Artemisia absinthium volatile oil by the bacterial reverse mutation assay in Salmonella typhimurium strains TA98 and TA100

ObjectiveTo investigate the mutagenic and antimutagenic activities of Artemisia absinthium L. (A. absinthium) essential oil by the bacterial reverse mutation assay in Salmonella typhimurium (S. typhimurium) strains.MethodsWater-distilled essential oil of A. absinthium collected from Ardabil, North-Western Iran, was investigated for mutagenic and antimutagenic activities. In present study, the mutagenic and antimutagenic activities of A. absinthium oil were investigated by the bacterial revere mutation assay in S. typhimurium TA98 and TA100 strains with and without S9 (microsomal mutagenesis assay).ResultsThe comparative mutagenicity effect was seen in 1.5 mg/plate by the bacterial reverse mutation assay in S. typhimurium TA98 strains, without S9 and the excellent antimutagenicity effect was seen in 1.5 mg/plate against S. typhimurium TA100, without S9.ConclusionsThe mutagenicity and antimutagenicity effects of the volatile oil of A. absinthium were seen without the presence of metabolic activation.