| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3455437 | Asian Pacific Journal of Tropical Medicine | 2015 | 7 Pages |
ObjectiveTo investigate the expression of HIP/PAP in hepatocellular carcinoma (HCC) patients and explore its role in migration and invasion of HCC.MethodsThe expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC, RT-PCR and Western blot. The correlation between clinicopathological features and HIP/PAP expression was analyzed. The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference, wound healing and Transwell assay.ResultsBoth mRNA and protein expression of HIP/PAP was upregulated in HCC tissues compared to tumor-adjacent tissue and correlated with poor tumor differentiation, advanced tumor stage and vascular invasion. HIP/PAP expression was also upregulated in HCC cells, and silencing its expression by specific siRNA could inhibit the invasion and migration of HCC cells.ConclusionsHIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
