Correlation between the Xba I polymorphism of apoB gene and serum lipid profiles in Li ethnic group

ObjectiveTo study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.MethodsTotal 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.ResultsThere were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X−/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X−/X+) genotype compared to homozygous (X−/X−) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X−/X+ and X−/X− genotype carriers.ConclusionsXba I polymorphism of apoB gene is correlated to the profiles of serum lipid level, X−/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.