| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3459903 | Chronic Diseases and Translational Medicine | 2015 | 9 Pages |
Abstract
Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI.
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Ming Tian, Yun-Chuan Yuan, Jia-Yi Li, Michael R. Gionfriddo, Rong-Chong Huang,