Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3461513 | Clinics in Liver Disease | 2009 | 13 Pages |
Abstract
Coagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.
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Authors
Santiago J. Munoz, R. Todd Stravitz, Don A. Gabriel,