| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3462626 | Contemporary Clinical Trials | 2015 | 6 Pages |
Abstract
The use of stepped wedge designs in cluster-randomized trials and implementation studies has increased rapidly in recent years but there remains considerable debate regarding the merits of the design. We discuss three key issues in the design and analysis of stepped wedge trials — time-on-treatment effects, treatment effect heterogeneity and cohort studies.
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Authors
James P. Hughes, Tanya S. Granston, Patrick J. Heagerty,