Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3467565 | European Journal of Internal Medicine | 2009 | 9 Pages |
Abstract
Angiogenesis is the physiological process of the formation of new blood vessels from pre-existing ones. Multiple molecules regulate angiogenesis, such as the vascular endothelial growth factor, angiopoietins, the fibroblast growth factor, the platelet-derived growth factor and the transforming growth factor-β. Angiogenesis plays an important role in the growth, progression and metastasis of a tumour. Inhibiting the angiogenic process or targeting existing tumour vessels can be used for treatment of tumours as an alternative or in parallel with conventional chemotherapy. Many anti-angiogenic factors are under investigation and some are already being used in clinical practice with various results.
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Authors
Nektaria Makrilia, Theodora Lappa, Vassilia Xyla, Ilias Nikolaidis, Kostas Syrigos,