Article ID Journal Published Year Pages File Type
3467931 European Journal of Internal Medicine 2011 8 Pages PDF
Abstract

IntroductionNeurosarcoidosis accounts for approximately 5% of cases of sarcoidosis.ObjectiveTo determine the frequency of Neurosarcoidosis in our setting and analyze the clinical–radiological findings and evolution of 30 patients consecutively diagnosed.MethodsThe medical records of patients with a diagnosis of Neurosarcoidosis were reviewed, and data regarding the clinical features, ancillary tests performed, treatment, and outcome were recorded. We revised the literature to summarize and discuss the previous clinical series of Neurosarcoidosis.ResultsIt accounted for 6.7% of all cases of sarcoidosis. Seven patients had definite diagnosis and 23 had probable diagnosis. The mean age at onset of Neurosarcoidosis was 48.3 years and 66.7% of patients were women. Neurologic clinical features were the first manifestation of Neurosarcoidosis in 70% of cases. Cranial neuropathy was present in 17 patients and 14 of them had facial palsy. The central nervous system was affected in 10 patients and the peripheral nervous system in 5. Chest disease, the most common extraneurologic manifestation, was present in 20 patients. All patients were treated with corticosteroids, and all those with central nervous system involvement had poor outcome.ConclusionNeurosarcoidosis requires a high degree of suspicion to establish the diagnosis. Central nervous system involvement is associated with a poor prognosis.

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