Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3479343 | Journal of the Formosan Medical Association | 2012 | 6 Pages |
Abstract
Neonatal seizures are common and often reflect a severe underlying neurologic dysfunction in neonates. Phenobarbital remains the mainstay of treatment of neonatal seizures, however, but it is ineffective in many patients and has adverse profiles in cognition. Furthermore, gamma-aminobutyric acid is excitatory early in brain development; therefore, treatment of neonatal seizures with phenobarbital must be cautious. In this review, we highlight the substantial progress that has been made in animal studies, and translate these results to the treatment of seizures in human neonates.
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Authors
Li-Tung Huang, You-Lin Tain, Ming-Chi Lai, San-Nan Yang,