| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3484054 | Journal of Nanjing Medical University | 2008 | 4 Pages |
ObjectiveTo identify potential serum markers of hepatic carcinoma in rats through Surface-Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry(SELDI-TOF-MS) Technology.MethodsA rat model of hepatic carcinoma was established. The serum samples of hepatic carcinoma and normal rats were analyzed via SELDI-TOF-MS Technology. The changes of the serum protein fingerprint patterns were observed between the experimental group of hepatic carcinoma and the controls. The analysis was conducted by statistical software-Biomarker Wizard.ResultsFifty-six protein peaks in the serums were found. Within m/z 0–20 000, the protein peaks of m/z 1158, 8 835 and 15 302 of hepatic carcinoma serums were obviously higher in the rat models compared with those in the controls(P < 0.01).ConclusionThree peaks were considered as potential biomarkers according to the serum protein fingerprint patterns of the hepatic carcinoma group and the control group.
