Study on relationship between perifollicular blood flow and in vitro fertilization-embryo transfer

ObjectiveTo study the relationship between perifollicular blood flow and follicule development, oocyte maturing rate, fertilizing rate, cleaving rate, embryo quality and the outcomes of embryo transfer.MethodsThe samples were selected from 66 suffers who underwent in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI). Eeach patients' perifollicular blood flow(diameter ≥ 12mm)was estimated on the day of human chorionic gonadotropin(HCG)administration.ResultsAmong 66 cycles,26(39.4%) cycles resulted in pregnancy. perifollicular blood flow resistance index(RI), peak systolic velocity/end diastasis velocity(S/D) of non-pregnant group was significantly higher than that of the pregnant group(P <0.004). When RI < 0.49, the pregnancy rates, fecundation rates, fertilization rates, metaphase numbers for the of second meiosis oocytes increased evidently(P <0.05), but there were no statistical difference in gonadotropin dosage, cycle frequency, infertility years, ages, estradiol(E2)on the day of HCG administration, numbers of oocyet retrieved and high-quality embryo rates(P >0.05). There were no statistical difference between non-pregnant group and pregnant group in S and D (P >0.05). There was no correlation between periFollicular blood flow RI and follicular diameter by linear regression analysis.ConclusionOur study shows that perifollicular blood flow RI and S/D are effective indices of predicting the pregnancy outcome of IVF-ET.