Scleroderma overlap syndrome with interstitial lung disease and pulmonary artery hypertension

Scleroderma overlap syndrome is a rare condition that presents as two or more connective tissue disorders in the same patient. Some of these connective tissue diseases are associated with a specific autoantibody profile, while others do not show any serological association. We report a case of a patient with scleroderma overlap syndrome who presented with fever, breathlessness, pulmonary fibrosis, pulmonary hypertension, interstitial lung disease, anaemia and clinical manifestations of systemic sclerosis and rheumatoid arthritis. The patient's laboratory results were strongly positive for antinuclear antibody (ANA) and anti-topoisomerase-1 antibody and seropositive for rheumatic fever and CCP antibodies.