Serum vaspin levels are associated with decreased insulin sensitivity in newly diagnosed type 2 diabetes mellitus in Bangladesh

ObjectivesThe present study aimed to explore the relationship of circulating vaspin levels with insulin sensitivity and anthropometric factors.MethodsThis study was conducted with 65 newly diagnosed type 2 diabetes mellitus (T2DM) patients with age-matched 65 healthy controls. Serum glucose was measured using glucose-oxidase method, lipid profiles by enzymatic end-point methods, and fasting insulin and vaspin levels were assessed with ELISA techniques. Homeostasis model assessment for insulin sensitivity (HOMA%S) and insulin secretory capacity (HOMA%B) were estimated from the fasting glucose and insulin levels using HOMA-CIGMA software.ResultsFasting serum insulin (μU/ml) was higher in the diabetic group than controls (16.0 ± 7.9 vs. 10.9 ±3.3, respectively, p =0.0001). The mean (±SD) HOMA%S of the diabetics was significantly lower than that of the controls (48 ±31 vs. 76±55, respectively, p = 0.001). The HOMA%B of the T2DM group was nearly 50% of that of the controls (71± 40 vs. 131 ±46, respectively, p = 0.001). The T2DM group exhibited significantly lower serum vaspin (ng/ml) levels than the controls (0.62 ±0.26 vs. 0.83± 0.28, respectively, p =0.001). Vaspin levels were negatively correlated with waist circumference (r =0.17, p =0.043) and positively correlated with HOMA%S (r =0.243, p =0.007) among all of the participants. The association of serum vaspin with diabetes remained highly significant (p =0.008) in binary logistic regression analysis performed after adjusting for the effects of confounders.ConclusionsSerum vaspin level is positively associated with insulin sensitivity and negatively correlated with serum glucose, BMI and waist-height ratio.