| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 370285 | Research in Autism Spectrum Disorders | 2012 | 5 Pages |
The current study examined the association between prenatal pregnancy complications (PPC) and childhood psychiatric symptoms in children with an autism spectrum disorder (ASD) and non-ASD children who were referred to a psychiatric clinic (Controls). Parents completed a DSM-IV-referenced rating scale and developmental history questionnaire. Participants were classified as having ≥1 PPC (+PPC) versus none (−PPC). Children with ASD were significantly more likely to have PPC than Controls. Intra-group comparisons demonstrated that children in the ASD + PPC group had more severe anxiety than ASD/−PPC group. The Control + PPC group obtained higher symptom ratings of inattention, hyperactivity, and oppositional behavior than Control/−PPC. Children in the ASD + PPC group were rated as having more severe anxiety and depression symptoms than Control + PPC. Dissimilar associations in ASD and non-ASD samples were found, suggesting divergent pathogenic processes in different clinical phenotypes.
► Children with ASD had more prenatal pregnancy complications (PPC) than Controls. ► ASD + PPC showed more severe anxiety than ASD/−PPC. ► ASD + PPC showed more severe anxiety and depression than Control + PPC. ► Control + PPC showed more disruptive behavioral symptoms than Control/−PPC. ► Suggests divergent pathogenesis related to PPC in children with and without ASD.
