Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
370777 | Research in Autism Spectrum Disorders | 2011 | 7 Pages |
Dysfunction of the prefrontal cortex has been previously reported in individuals with Asperger's disorder. In the present study, we used multi-channel near-infrared spectroscopy (NIRS) to detect changes in the oxygenated hemoglobin concentration ([oxy-Hb]) during two verbal fluency tasks. The subjects were 20 individuals with Asperger's disorder and 18 age- and IQ-matched healthy controls. The relative [oxy-Hb] in the prefrontal cortex was measured during the category and letter fluency tasks. The mean total [oxy-Hb] during the category fluency task did not differ significantly between the groups; however, during the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. These results suggested task-relevant or task-specific prefrontal dysfunction in persons with Asperger's disorder.
Research highlights► The mean total [oxy-Hb] measured with NIRS during the category fluency task did not differ significantly between persons with Asperger's disorder and controls. ► During the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. ► Task-relevant or task-specific prefrontal dysfunction exists in persons with Asperger's disorder.