Attention deficit hyperactivity disorder (ADHD) in childhood epilepsy

ADHD and epilepsy common are both common childhood disorders and both can have significant negative consequences on a child's behavioural, learning, and social development. Both conditions can co-occur and population studies suggest that the prevalence of ADHD in childhood epilepsy is between 12 and 17%. The prevalence of epilepsy in ADHD is lower but it is not clear if the rate of epilepsy is higher in ADHD populations than in the general population. There is a higher occurrence of ADHD – Primarily Inattentive subtype in children with epilepsy and the reasons for this are not altogether clear but attention difficulties are very prevalent in childhood epilepsy. Seizure/epilepsy variables do not appear to be important correlates in most cases of ADHD in epilepsy although they may play a role in some cases. Individuals with both epilepsy and intellectual disability may be at higher risk for significant ADHD symptoms although screening and assessment in children with intellectual disability and epilepsy may be challenging. Children with epilepsy and ADHD are likely to be at higher risk for more negative outcomes in school and in terms of quality of life compared with children with epilepsy alone. Published studies on the treatment of ADHD in childhood epilepsy have focussed exclusively on the use of psychopharmacology and particularly methylphenidate. Although methylphenidate appears to be effective for some children with epilepsy the issue of whether it may lower seizure threshold continues to be debated. Children with epilepsy are at significant risk for ADHD and there is a need for more studies focussing on safe and efficacious interventions for symptoms of ADHD in this population.

Research highlights► Population studies suggest that 12–17% of children with epilepsy meet the criteria for ADHD. ► Children with epilepsy are particularly at risk for symptoms associated with ADHD Primarily Inattentive subtype. ► Screening and assessment in this population can be complex with a need for consideration of the effects of seizures and AEDs in relation to manifestation of ADHD symptoms. ► Treatment of ADHD symptoms via psychopharmacology appears warranted but safety concerns persist regarding effects of seizure threshold. ► ADHD is a common co-morbid condition in childhood epilepsy and thus surveillance and screening are needed.