Modulación del sistema de supervivencia y maduración del linfocito B: presente y futuro de una nueva estrategia terapéutica en el lupus eritematoso sistémico

Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their survival and maturation, have contributed to the development of new therapeutic strategies in recent years.