Antiphospholipid syndrome

Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibody production may lead to a hypercoagulable state, pregnancy failure and/or a multitude of other systemic manifestations. In recent times, research into the antiphospholipid antibodies has strengthened our understanding of the pathogenic process, and encouraged improved detection of antiphospholipid antibodies. However, the precise nature of the pathology of APS, as well as the management of this disorder, remain challenging. This review outlines the key features of APS, including the laboratory tests and interpretation, and offers advice regarding management of patients with APS both in the medical and obstetric settings.