Article ID Journal Published Year Pages File Type
3824744 Progrès en Urologie 2013 12 Pages PDF
Abstract
Renal mass increases after nephrectomy thanks to two components, one is immediately due to the rise of glomulary capillary vascular flow, other is linked to cellular modifications with hyperplasia stage which precedes hypertrophy stage. After nephrectomy, young animals show higher renal adaptability than adults. Similarly, the sex influences the remnant kidney parenchyma volume, the increase of glomerular filtration, the hyperplasia's intensity or length, the hypertrophy's metabolic pathways and the glomerular and tubular cells' injury. There is no question that renal compensatory is regulated by hormones such as IGF-1, TGFβ-1 and Ang-II.
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