A Dutch patient with diffuse panbronchiolitis successfully treated with clarithromycine

SummaryA case report of a 26-year-old Caucasian male with a medical history of chronic sinusitis and a “difficult to treat” asthma bronchiale is described. After a period of 6 years intensive medical treatment and diagnostic procedures, a diffuse panbronchiolitis (DPB) was diagnosed, confirmed by histological examination. This case report describes the successful outcome of macrolide treatment in this patient. Despite the low incidence of DPB in western countries, physicians must be aware of this orphan disorder in order to provide adequate therapy.