Intoxicaciones por antidiabéticos orales en España. Análisis y evolución a lo largo de 13 años (1991-2003)

The total number of poisonings was of 309 subjects, being more frequent in women 52.9% versus 47.1% in men. The clinical poisonings were classified in asymptomatic 13.9%, low symptoms 49.5% moderate serious 31.3% serious 5.1%. The pharmacologic group with greater number of poisonings was of sulfonilurea 66.5%, within this group the glyburide one. In the last years poisonings with but of a drug appear appearing in the 2002 poisoning by triple therapy (sulfonilurea-metformin and alpha-glucosidase inhibitor). It is important to emphasize the absence of mortality and the modification of prescription increase of cases of metformin and diminution of alpha-glucosidase inhibitor. In our study we emphasized the greater one I number of poisonings in group of suckling babies and children with respect to the adults. Everything shows the importance of the correct prescription and use of the oral antidiabetics.