| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3828494 | Revista Clínica Española | 2007 | 5 Pages |
IntroducciónLa colitis colágena (CC) es una entidad poco frecuente y de buen pronóstico que desde un punto de vista clÃnico pertenece al grupo de las diarreas crónicas acuosas.ObjetivoAnalizar las caracterÃsticas epidemiológicas, clÃnicas y evolutivas de un grupo de 18 pacientes diagnosticados de CC, asà como la respuesta al tratamiento.Material y métodosSe realiza un estudio retrospectivo de las biopsias endoscópicas de colon realizadas en el Hospital de León durante 5 años, seleccionándose las que cumplen los criterios histológicos de CC.ResultadosSe obtiene un total de 18 casos con una incidencia de 1,25/105 habitantes/año. La edad media era de 66,7 años, sin encontrarse diferencias de sexo. El tiempo hasta el diagnóstico fue de 10 meses y existe una posible relación con la toma de antiinflamatorios no esteroideos (46%), lansoprazol (42,8%), tabaquismo (41,6%), asà como con enfermedades autoinmunes (30,7%). Hubo respuesta favorable al tratamiento con mesalazina en 2 de los 3 pacientes tratados con ésta y los 2 pacientes tratados con budesonida evolucion aronde forma favorable.ConclusionesEs importante la toma de multiples biopsias de colon ante un caso de diarrea crónica acuosa para realizar el diagnóstico de la CC, aun cuando la endoscopia sea normal. En la etiologÃa pueden estar implicados ciertos fármacos y enfermedades autoinmunes.
IntroductionCollagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas.ObjectiveTo study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment.Material and methodsThis is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected.ResultsA total of 18 cases with an incidence of 1.25/105 inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflamatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide.ConclusionIt is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology.
