Síndrome de secreción inadecuada de hormona antidiurética por fármacos

The syndrome of inappropriate antidiuretic hormone (or vasopressin) secretion (SIADH) has a very varied aetiology which presents with hyponatraemia, low plasma and urine osmolality, and an inappropriately high natriuresis. on being a diagnosis by exclusion, it is important to rule out states that present with decreased effective blood volume, and primary polydipsia. In addition, the acid-base, potassium, cardiac, renal, adrenal and thyroid function should be normal. Along with malignancies and infections, drugs are a common and increasing cause of this syndrome. Its diagnosis and treatment are often straightforward, and are often dealt with in primary care. We describe four cases of SIADH attributed to drugs, and review the general characteristics of the condition.