Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3840240 | Translational Research | 2013 | 15 Pages |
Abstract
Adoptive immunotherapy using gene engineered T cells is a promising and rapidly evolving field, and the ability to engineer T cells to manifest desired phenotypes and functions has become a practical reality. In this review, we describe and summarize current thought about gene engineering of T cells. We focus on the identified requirements for the successful application of T cell based immunotherapy and discuss gene-therapy based strategies that address these requirements and have the potential to enhance the successful implementation of this promising approach to treat cancer.
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Authors
Saar Gill, Michael Kalos,