Solid Pseudopapillary Neoplasm of the Pancreas: Report of Two Cases and Review of the Literature

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare low-grade malignant-potential epithelial tumor that predominantly affects young women aged 20–35 years with a mean age of 22 years. It is currently categorized in the World Health Organization classification under exocrine pancreatic tumor. Here, we present two cases of SPN with initial presentation of large intra-abdominal masses. Both patients underwent successful en bloc distal pancreatectomy and splenectomy. Local recurrence and distant metastasis were not detected at the follow up at 21 months and 9 years respectively. In summary, a large, well-encapsulated cystic mass in the pancreas of a young woman should raise suspicion of SPN.