Article ID Journal Published Year Pages File Type
3848023 American Journal of Kidney Diseases 2014 7 Pages PDF
Abstract
Despite increases in precision of the treatment effect, eGFR declines less than a doubling of serum creatinine value did not consistently improve statistical power of the clinical trials due to attenuation of the treatment effect. Attenuation of the treatment effect appears to be due in part to acute effects of ARBs on eGFR. These findings should be taken into account when using lesser eGFR declines as alternative end points for clinical trials.
Related Topics
Health Sciences Medicine and Dentistry Nephrology
Authors
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