Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3848330 | American Journal of Kidney Diseases | 2013 | 11 Pages |
Abstract
Variable rates of disease observed between members of different continental population groups may be mediated by inherited factors, environmental exposures, or their combination. This article provides evidence in support of differential allele frequency distributions that underlie the higher rates of nondiabetic kidney disease in the focal segmental glomerulosclerosis spectrum of disease and lower rates of coronary artery calcified atherosclerotic plaque and osteoporosis in populations of African ancestry. With recognition that these and other common complex diseases are affected by biological factors comes the realization that targeted manipulation of environmental exposures and pharmacologic treatments will have different effects based on genotype. The present era of precision medicine will couple one's genetic makeup with specific therapies to reduce rates of disease based on the presence of disease-specific alleles.
Related Topics
Health Sciences
Medicine and Dentistry
Nephrology
Authors
Barry I. MD, Jasmin PhD, Nicholette D. PhD,