Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3850134 | American Journal of Kidney Diseases | 2010 | 4 Pages |
Abstract
DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe adverse drug reaction with significant mortality, characterized by erythroderma, fever, lymphadenopathy, and visceral involvement. We report a case of multivisceral DRESS syndrome with posterior multifocal placoid pigment epitheliopathy and acute tubulointerstitial nephritis responsible for dialysis-dependent acute kidney failure in the context of reactivation of Epstein-Barr virus infection. Because of resistance of the skin and kidney manifestations to prolonged corticosteroid therapy, a 6-month course of oral cyclophosphamide resulted in complete recovery of all symptoms. To our knowledge, this is the first case showing the efficacy of cyclophosphamide in severe DRESS syndrome.
Related Topics
Health Sciences
Medicine and Dentistry
Nephrology
Authors
Emilie MD, Eva MD, François MD, Mokrane MD, Emilie MD, Gérard MD, Guy MD, Frank MD, PhD,