Treatment of Pediatric IgA Nephropathy

IgA nephropathy is the most common chronic glomerulopathy in children and young adults. Although most of the early studies on pediatric IgA nephropathy concluded that it was a benign condition, more recent data have shown that a significant proportion of children progress to end-stage renal disease. It is now obvious that IgA nephropathy in children is not as benign as previously thought. Physicians who care for children with IgA nephropathy should be aware of this risk of progression to renal insufficiency and make treatment a priority. Strict attention should be given to modify any coexisting morbidities that may further predispose young patients to renal deterioration. The pharmacologic agents and therapeutic options used to manage this common disease are reviewed, and a recommended approach is presented. [Hong Kong J Nephrol 2007;9(2):70–6]