| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3856135 | Journal of Renal Nutrition | 2011 | 5 Pages |
Abstract
Administration of indoxyl sulfate to hypertensive rats reduced renal expression of klotho and promoted cell senescence with expression of senescence-related proteins, such as p16INK4a, p21WAF1/CIP1, p53, and Rb, which was accompanied by renal fibrosis.
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Authors
Ayinuer MD, PhD, Hidehisa PhD, Yusuke Higuchi, Fuyuhiko MS, Toshimitsu MD, PhD,