Inhibition of NMDAR Reduces Bladder Hypertrophy and Improves Bladder Function in Cyclophosphamide Induced Cystitis

Article ID	Journal	Published Year	Pages	File Type
3858719	The Journal of Urology	2015	8 Pages	PDF

Abstract

Findings suggest that NMDAR activity has a role in cystitis induced bladder hypertrophy and overactivity. NMDAR mediated Akt activation may underlie the mechanism of bladder dysfunction.

Keywords

MK-801 D-2-amino-5-phosphonopentanoate CCH NMDAR N-methyl-d-aspartate NGF CyP PI3K d-AP5 Akt Bladder outlet obstruction BOO Overactive Interstitial dizocilpine Cystitis Cyclophosphamide nerve growth factor phosphorylated phospho phosphoinositide 3-kinase Urinary bladder Hypertrophy protein kinase B Carbachol Collagen N-methyl-d-aspartate receptor Receptors

Related Topics

Health Sciences Medicine and Dentistry Nephrology

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Inhibition of NMDAR Reduces Bladder Hypertrophy and Improves Bladder Function in Cyclophosphamide Induced Cystitis

Authors

Miao Liu, Shanwei Shen, Derek M. Kendig, Sunila Mahavadi, Karnam S. Murthy, John R. Grider, Li-Ya Qiao,