Article ID Journal Published Year Pages File Type
3863098 The Journal of Urology 2013 5 Pages PDF
Abstract
Increasing urine pH greatly increased the efficacy of thiol drugs to solubilize cystine in a clinically relevant time frame. These findings suggest that to maximize the benefit of thiol drugs alkali therapy should be used in conjunction with thiol drugs with the goal of keeping urine pH at 7.5 or above. Clinical trials are needed to confirm these in vitro findings.
Related Topics
Health Sciences Medicine and Dentistry Nephrology
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