Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3863098 | The Journal of Urology | 2013 | 5 Pages |
Abstract
Increasing urine pH greatly increased the efficacy of thiol drugs to solubilize cystine in a clinically relevant time frame. These findings suggest that to maximize the benefit of thiol drugs alkali therapy should be used in conjunction with thiol drugs with the goal of keeping urine pH at 7.5 or above. Clinical trials are needed to confirm these in vitro findings.
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Authors
Daniel M. Asplin, John R. Asplin,