Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3866732 | The Journal of Urology | 2012 | 6 Pages |
Abstract
In vitro interleukin-6 elicitation, an established marker to determine bacterial virulence, correlates inversely with clinical urinary tract infection severity. Less virulent, high cytokine producing E. coli were more likely to cause cystitis and were more commonly found in patients with neurogenic bladder and nonneurogenic bowel and bladder dysfunction, whereas higher virulence isolates were more likely to produce febrile urinary tract infections and to affect children with primary vesicoureteral reflux and no underlying etiology. These findings suggest that bacteria of different virulence levels may be responsible for differences in severity of pediatric urinary tract infections and may vary among different underlying uropathies.
Keywords
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Nephrology
Authors
Douglas W. Storm, Ashay S. Patel, Dennis J. Jr., Birong Li, Stephen A. Koff, Sheryl S. Justice,