Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3867504 | The Journal of Urology | 2012 | 6 Pages |
Abstract
We present the first identification to our knowledge of small leucine-rich proteoglycans in normal and abnormal bladder tissue, and their differential expression in the process of bladder fibrosis, consistent with experimental findings in other anatomical sites. Further investigation into small leucine-rich proteoglycan expression and regulation may allow for the development of new antifibrotic therapeutics.
Keywords
PBSGAPDHRT-qPCRproteoglycansSLRPPBOOinflammationPartial bladder outlet obstructionurinary bladder neck obstructionPhosphate buffered salineFibrosispolymerase chain reactionreverse transcriptase quantitative polymerase chain reactionPCRsmall leucine-rich proteoglycanglyceraldehyde 3-phosphate dehydrogenase
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Authors
Conrad C. MacIejewski, Dariush Honardoust, Edward E. Tredget, Peter D. Metcalfe,