| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3867563 | The Journal of Urology | 2010 | 6 Pages |
Abstract
To our knowledge we provide the first report of the in vivo significance of p27KIP1 in the regulation of detrusor function using a cystometric approach. We identified a role for p27KIP1 in protecting against dysregulated smooth muscle cell proliferation, bladder capacity and detrusor compliance under normotensive conditions.
Keywords
PCNADetrusor leak point pressureNFATSMCDLPPRT-PCRCKICDKProliferating Cell Nuclear AntigenBladder outlet obstructionurinary bladder neck obstructionBOOSmooth muscle cellNuclear Factor of Activated T CellsUrinary bladderCDK inhibitorMicehyperplasiaReverse transcriptase-polymerase chain reactioncyclin-dependent kinase
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Authors
Robert A. Niederhoff, Scott R. Manson, Ahmad Tawfik, Paul F. Austin,