| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3873644 | The Journal of Urology | 2009 | 7 Pages |
Abstract
PTEN inactivation and neuroendocrine differentiation were related to refractoriness to bicalutamide therapy. These results support the hypothesis that neuroendocrine differentiation is caused by activation of the serine threonine kinase Akt pathway, which results from PTEN inactivation.
Keywords
ADTBicalutamidePI3KPTEN phosphohydrolaseCGANEDBCRPSATMAECeProstate specific antigenHERIHCImmunohistochemistryNeuroendocrine differentiationADT, Androgen deprivation therapyRadical prostatectomyProstate cancerTreatment failureepidermal growth factorBiochemical recurrenceExtracapsular extensionphosphatase and tensin homologue deleted on chromosome 10Phosphatidylinositol 3-kinaseTissue microarrayProstatic neoplasmsPtenChromogranin ASeminal vesicleLymph node
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Authors
Won Sik Ham, Nam Hoon Cho, Won Tae Kim, Hee Jeong Ju, Jin Sun Lee, Young Deuk Choi,