Multifocal High Grade Prostatic Intraepithelial Neoplasia is a Significant Risk Factor for Prostatic Adenocarcinoma

Patients with an initial diagnosis of high grade prostatic intraepithelial neoplasia, especially when multifocal, are at greater risk for subsequent prostatic adenocarcinoma than those with a benign diagnosis. Results suggest that followup should be more rigorous in patients with multifocal high grade prostatic intraepithelial neoplasia.