| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3875990 | The Journal of Urology | 2006 | 5 Pages |
Abstract
This study showed that intravesical nociceptin/orphanin FQ but not placebo inhibited the micturition reflex in patients with neurogenic detrusor overactivity incontinence, and demonstrated the clinical efficacy of nociceptin/orphanin FQ during 10 days of treatment. These findings support the use of nociceptin/orphanin FQ peptide receptor agonists as an innovative therapeutic approach for controlling detrusor overactivity incontinence.
Keywords
DOIdetrusor overactivity incontinenceCISCTrospium chloridePropiverineNOPRTXAfferentMBPIEFN/OFQnociceptin/orphanin FQSpinal cord injuriesBOTNDOUrinary incontinenceNeurogenic detrusor overactivityDetrusor overactivityClean intermittent self-catheterizationTolterodineresiniferatoxinbotulinum toxinBladder capacityBladderNeuronsNeurogenicNociceptin receptor
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Authors
Massimo Lazzeri, Girolamo Calò, Michele Spinelli, Silvia Malaguti, Remo Guerrini, Severo Salvadori, Patrizia Beneforti, Domenico Regoli, Damiano Turini,