| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3877010 | The Journal of Urology | 2007 | 7 Pages |
Abstract
We successfully observed that primary urothelium cultures can be genetically manipulated and recombined with undifferentiated mesenchyma to grow bladder tissue. By attenuating transforming growth factor-β signaling in the urothelium superior bladder tissue growth occurred, suggesting that transforming growth factor-β is a growth inhibitor in this organ system.
Keywords
TGF-βPAI-1ABCDABFACSeGFP3,3′-diaminobenzidine tetrahydrochlorideIHCImmunohistochemistrytransforming growth factorstransforming growth factor-βTransfectionSMASmooth muscle α-actinfluorescence activated cell sortingBladderAvidin-biotin complexMesodermPlasminogen activator inhibitor type 1polymerase chain reactionPCRUrothelium
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Authors
Siam Oottamasathien, Karin Williams, Omar E. Franco, Marcia L. Wills, John C. Thomas, Ali-Reza Sharif-Afshar, Romano T. DeMarco, John W. III, Neil A. Bhowmick, Simon W. Hayward, John C. IV,