| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3884315 | Kidney International | 2008 | 4 Pages |
Abstract
In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K+ channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.
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Authors
Seth L. Alper,