Article ID Journal Published Year Pages File Type
3889873 Kidney International 2006 9 Pages PDF
Abstract

Patients on maintenance peritoneal dialysis (PD) are frequently complicated with volume overload. In this study, we sought to evaluate troponin T testing alone or in combination with echocardiographic measures in predicting cardiovascular congestion in PD patients. This was a prospective study of 222 chronic PD patients with echocardiography and measurement of serum troponin T carried out at baseline. Patients were followed for 3 years or until death. The end point was first episode of cardiovascular congestion. Troponin T emerged as an independent predictor of cardiovascular congestion (hazard ratio, 2.98, 95% confidence intervals (CI), 1.19–7.42) in a multivariable Cox regression model, including also left ventricular mass index (LVMi) and ejection fraction (EF). Patients with troponin T>median (0.06 μg/l) and EF≤50% and patients with troponin T>median but EF>50% had a 3.10-fold (95% CI, 1.71–5.63) and 1.88-fold (95% CI, 1.05–3.38) adjusted risk of cardiovascular congestion, respectively, than those with troponin T≤median and EF>50%. Patients with troponin T>median and LVMi≥median (96.23 g/m2.7) had a 2.68-fold (95% CI, 1.39–5.19) adjusted risk of cardiovascular congestion than those with troponin T≤median and LVMi

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