| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3896280 | Seminars in Nephrology | 2015 | 5 Pages |
Abstract
SummaryKidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.
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Authors
Beatrice Goilav, Chaim Putterman,