| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3897851 | Urology | 2016 | 8 Pages |
Abstract
Expression of the tACE/Ang-(1-7)/Mas axis was downregulated during tIR. Administration of exogenous Ang-(1-7) prior to reperfusion rescued tACE and Mas expression and protected against germ cell apoptosis and oxidative stress. Increased NO generation and activation of the PI3K/Akt signaling pathway may have partially contributed to these effects. The tACE/Ang-(1-7)/Mas axis likely plays a role in the maintenance of normal testis physiology and spermatogenesis.
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Authors
May Al-Maghrebi, Waleed M. Renno,