Differentiation of Human Adipose-derived Stem Cells Co-cultured With Urothelium Cell Line Toward a Urothelium-like Phenotype in a Nude Murine Model

The results of our study have demonstrated that ASCs could be differentiated toward the urothelium-like phenotype when they were coimplanted in direct contact with cells of a mature urothelium cell line, and the proportion of differentiated cells increased from 2 to 4 weeks. The differentiation potential of ASCs toward the urothelial cell type suggests that ASCs might have potential to be used in urinary tract repair with a tissue engineering approach in the future.