Long-term Follow-up of Men With Isolated High-grade Prostatic Intra-epithelial Neoplasia Followed by Serial Delayed Interval Biopsy

Men with isolated HGPIN have a continued risk of developing prostate cancer during long-term follow-up, regardless of the changes in the serum PSA level. Collectively, the relatively high likelihood of organ confinement and clinically significant cancer suggest empiric DIBx every 2-3 years could be a valuable tool in the follow-up of men with isolated HGPIN found by extended core biopsy.